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With this readout, we aim to showcase a randomized dataset that shows one or both of the trial's pelareorep-based treatment regimens numerically outperforming the paclitaxel monotherapy arm on key metrics such as overall response rate and progression-free survival. We believe this result would represent a key inflection point, as it would confirm our breast cancer program's prior statistically significant results, accelerate its advancement into a registrational trial, and bolster our business development prospects. Coffey continued, 'In pancreatic cancer, interim results from pelareorep's GOBLET trial showed an objective response rate that was nearly three times greater than those recorded in historical control trials. These data supported a subsequent Fast Track designation from the FDA, which will be incredibly valuable as we work with the agency and other key stakeholders to identify the optimal path to registration. GOBLET's data also transformed our pancreatic cancer program into our pipeline's second core pillar, thereby adding an important value driver that strengthens our foundation for sustained growth. Thirteen patients were evaluable for efficacy as of the poster's cut-off date October 12, , with one achieving a confirmed complete response and eight achieving a partial response PR following treatment with the combination of pelareorep, Roche's anti-PD-L1 checkpoint inhibitor atezolizumab, and the chemotherapeutic agents gemcitabine and nab-paclitaxel. Based upon these results and favorable safety data from GOBLET's pancreatic cancer cohort, Oncolytics will continue to engage with regulators to determine the optimal and most expeditious registration-enabling pathway. With this designation, Oncolytics' pancreatic cancer program may be eligible for more frequent meetings and communications with the FDA to review development plans and discuss the data needed to support approval. Furthermore, programs that receive Fast Track designation may be eligible for Accelerated Approval and Priority Review in certain situations. Fourteen patients were evaluable for efficacy as of the trial's data cutoff date September 26, , with thirteen achieving disease control PR or stable disease , twelve achieving tumor shrinkage from baseline, and seven achieving a PR. One patient achieved a PR at week 8, maintained the PR, and remained on study at week 48, providing evidence of the durable clinical benefit from pelareorep-paclitaxel combination therapy. Safety data showed that the studied combination was well tolerated, with no dose-limiting toxicities or serious adverse events reported. Oncolytics expects to announce overall response rate and progression-free survival data from BRACELET-1 at a major medical meeting in the second quarter of The quarter-over-quarter decrease was largely due to lower share-based compensation expense, partly offset by higher office expenses. The year-over-year decrease was primarily due to lower public company-related costs.

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